Yes, you can skip One Piece filler. Out of 1,160 total episodes, only 94 are filler — that's an 8.1% filler rate, the lowest of any long-running shonen anime. Skipping them won't affect the main story, won't change which characters you meet, and won't lock you out of any plot points later.
But “skip all filler” is the wrong question for most viewers. The right question is: for the arc I'm currently watching, should I skip the filler attached to it, or push through? Some filler arcs are short, painless, and worth the 90 minutes — like the legendary G-8 Arc, which fans rate as one of the best stretches of the entire show despite being 100% anime-original. Others are 11 episodes of unrelated detours that drop you out of the main plot for hours.
This guide gives you a Saga-by-Saga skip plan, plus a “should you skip it?” verdict for each of the 13 pure filler arcs in One Piece. Use the Saga plan if you're already watching and need a quick answer. Use the per-arc verdicts if you want to know the exceptions before you commit.
If you want a stricter approach — every canon episode listed without filler clutter — see the canon-only watch path. If you want the underlying data, every filler episode is enumerated on the filler list. This page is the decision page: not what to watch, but what to confidently skip.